Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model.

Voabil, Paula; Liberal, Joana; Leal, Ermelindo C; Bauer, Jacques; Cunha-Vaz, José; Santiago, Ana Raquel; Ambrósio, António Francisco

Voabil, Paula; Liberal, Joana; Leal, Ermelindo C; Bauer, Jacques; Cunha-Vaz, José; Santiago, Ana Raquel; Ambrósio, António Francisco.

Affiliation

Voabil P; Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Ophthalmic Res ; 58(3): 150-161, 2017.

Article in En | MEDLINE | ID: mdl-28793297

Subject(s)

Calcium Dobesilate/pharmacology; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1/complications; Diabetic Retinopathy/prevention & control; Inflammation/prevention & control; Oxidative Stress/drug effects; Retina/pathology; Animals; Apoptosis/drug effects; Blood-Retinal Barrier/drug effects; Diabetes Mellitus, Type 1/metabolism; Diabetic Retinopathy/diagnosis; Diabetic Retinopathy/metabolism; Hemostatics/pharmacology; Inflammation/metabolism; Inflammation/pathology; Male; Rats; Rats, Wistar; Retina/metabolism

Key words

Calcium dobesilate; Cytokines; Diabetic retinopathy; Inflammation; Nitrosative stress; Oxidative stress

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retina / Calcium Dobesilate / Oxidative Stress / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 1 / Diabetic Retinopathy / Inflammation Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Ophthalmic Res Year: 2017 Document type: Article Affiliation country: Portugal

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