Neuroprotective activity of cannabinoid receptor-2 against oxidative stress and apoptosis in rat pups having experimentally-induced congenital hypothyroidism.

Alcigir, Mehmet Eray; Dogan, Halef Okan; Atalay Vural, Sevil; Yilmaz, Fatma Meric

Alcigir, Mehmet Eray; Dogan, Halef Okan; Atalay Vural, Sevil; Yilmaz, Fatma Meric.

Affiliation

Alcigir ME; Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Diskapi-Ankara, 06110, Turkey.
Dogan HO; Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, 58140, Turkey.
Atalay Vural S; Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Diskapi-Ankara, 06110, Turkey.
Yilmaz FM; Department of Biochemistry, Faculty of Medicine, Yildirim Bayezit University, Ankara, 06800, Turkey.

Dev Neurobiol ; 77(11): 1334-1347, 2017 11.

Article in En | MEDLINE | ID: mdl-28799288

Subject(s)

Apoptosis/drug effects; Congenital Hypothyroidism/prevention & control; Neuroprotective Agents/therapeutic use; Oxidative Stress/drug effects; Receptor, Cannabinoid, CB2/metabolism; Animals; Animals, Newborn; Brain/pathology; Caspase 3/metabolism; Caspase 9/metabolism; Disease Models, Animal; Female; Male; Nitric Oxide Synthase/therapeutic use; Nitric Oxide Synthase Type II/metabolism; Nitric Oxide Synthase Type III/metabolism; Rats; Rats, Wistar; Reflex/drug effects; Thyroid Hormones/metabolism

Key words

central nervous system; critical period; rat pup; thyroid hormone deficiency

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Oxidative Stress / Neuroprotective Agents / Congenital Hypothyroidism / Receptor, Cannabinoid, CB2 Type of study: Prognostic_studies Limits: Animals Language: En Journal: Dev Neurobiol Journal subject: BIOLOGIA / NEUROLOGIA Year: 2017 Document type: Article Affiliation country: Turkey Country of publication: United States

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