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Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Analysis.
Gupta, Neeraj; Hanley, Michael J; Venkatakrishnan, Karthik; Bessudo, Alberto; Rasco, Drew W; Sharma, Sunil; O'Neil, Bert H; Wang, Bingxia; Liu, Guohui; Ke, Alice; Patel, Chirag; Rowland Yeo, Karen; Xia, Cindy; Zhang, Xiaoquan; Esseltine, Dixie-Lee; Nemunaitis, John.
Affiliation
  • Gupta N; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
  • Hanley MJ; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
  • Venkatakrishnan K; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
  • Bessudo A; California Cancer Associates for Research and Excellence, San Diego, CA, USA.
  • Rasco DW; South Texas Accelerated Research Therapeutics, San Antonio, TX, USA.
  • Sharma S; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • O'Neil BH; Indiana University Simon Cancer Center, Indianapolis, IN, USA.
  • Wang B; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
  • Liu G; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
  • Ke A; Certara USA, Inc, Princeton, NJ, USA.
  • Patel C; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
  • Rowland Yeo K; Certara USA, Inc, Princeton, NJ, USA.
  • Xia C; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
  • Zhang X; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
  • Esseltine DL; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
  • Nemunaitis J; Mary Crowley Cancer Research Center, Dallas, TX, USA.
J Clin Pharmacol ; 58(2): 180-192, 2018 02.
Article in En | MEDLINE | ID: mdl-28800141
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boron Compounds / Proteasome Inhibitors / Cytochrome P-450 CYP3A Inducers / Cytochrome P-450 CYP3A Inhibitors / Glycine / Antineoplastic Agents Type of study: Clinical_trials Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2018 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boron Compounds / Proteasome Inhibitors / Cytochrome P-450 CYP3A Inducers / Cytochrome P-450 CYP3A Inhibitors / Glycine / Antineoplastic Agents Type of study: Clinical_trials Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2018 Document type: Article Country of publication: United kingdom