[Expression of Wnt5b in patients with HBV-related hepatocellular carcinoma and its clinical significance].
Nan Fang Yi Ke Da Xue Xue Bao
; 37(8): 1071-1077, 2017 Aug 20.
Article
in Zh
| MEDLINE
| ID: mdl-28801288
ABSTRACT
OBJECTIVE:
To investigate the expression of Wnt5b in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) tissues and its correlation with the clinicopathological parameters.METHODS:
Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemical staining were employed to measure Wnt5b mRNA and protein expressions in two groups of HBV-related HCC patients (100 cases in each) selected from a cohort of 289 cases with HBV-related HCC using simple random sampling method. The correlation of Wnt5b expression with the clinicopathological parameters and the prognosis of HCC patients was analyzed.RESULTS:
Wnt5b mRNA expression was significantly higher in HCC tissues than that of adjacent noncancerous tissues in 65.0% (65/100) of the cases, and the positivity rate of Wnt5b protein was significantly higher in HCC tissues than that of adjacent noncancerous tissues (58.0% vs 22.0%, P<0.05). Wnt5b expression was significantly correlated with the tumor size (P<0.05), tumor number (P<0.01, only at the protein level), tumor differentiation (P<0.01, only at the protein level), TNM stage (P<0.05), BCLC stage (P<0.05), metastasis (P<0.05) and recurrence (P<0.01). The patients with up-regulated Wnt5b mRNA and protein had a shorter relapse-free survival (P<0.01).CONCLUSION:
s Up-regulated Wnt5b might contribute to the progression of HBV-related HCC and predicts a poor prognosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
Zh
Journal:
Nan Fang Yi Ke Da Xue Xue Bao
Year:
2017
Document type:
Article