Association between pregravid physical activity and family history of stroke and risk of stillbirth: population-based cohort study.
BMJ Open
; 7(8): e017034, 2017 Aug 11.
Article
in En
| MEDLINE
| ID: mdl-28801430
ABSTRACT
OBJECTIVES:
To evaluate whether family history of disease and pregravid lifestyle and cardiovascular risk factors are associated with subsequent stillbirth delivery.DESIGN:
Prepregnancy cohort study.SETTING:
Cohort Norway regional health surveys (1994-2003) linked to Medical Birth Registry of Norway for deliveries through 2012.PARTICIPANTS:
13 497 singleton births (> 22 weeks gestation) in 8478 women. MAIN OUTCOMEMEASURE:
Risk of stillbirth evaluated by Poisson regression.RESULTS:
Mean (SD) length of follow-up was 5.5 (3.5) years. In analyses adjusting for baseline age and length of follow-up, ≥3 hours of baseline past-year vigorous physical activity per week (resulting in shortness of breath/sweating) was associated with increased risk of stillbirth compared with <1 hour/week of vigorous activity (incidence rate ratio, IRR 2.46; 95% CI 1.23 to 4.90). In contrast, baseline past-year light physical activity of ≥3 hours per week associated with reduced risk of stillbirth compared with <3 hours of light physical activity per week (IRR 0.53; 95% CI 0.30 to 0.93). A family history of stroke associated with increased risk of stillbirth delivery (IRR 2.53; 95% CI 1.06 to 6.01). Because overweight/obese women may experience shortness of breath and sweating with less physical exertion than normal weight women, a sensitivity analysis was conducted limited to women with a normal BMI (> 18.5 and <25 kg/m2). Vigorous activity of ≥3 hours per week (IRR of 4.50; 95% CI 1.72 to 11.79) and a family history of stroke (IRR of 3.81; 95% CI 1.31 to 11.07) were more strongly related to stillbirth risk among women with a normal BMI than that observed for all women combined. Established risk factors also associated with stillbirth risk.CONCLUSIONS:
The study identified physical activity and family history of stroke as potential new risk factors for stillbirth delivery.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications
/
Exercise
/
Family
/
Stroke
/
Stillbirth
/
Physical Exertion
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Europa
Language:
En
Journal:
BMJ Open
Year:
2017
Document type:
Article
Affiliation country:
Norway