Pharmacological modulation of Acid-Sensing Ion Channels 1a and 3 by amiloride and 2-guanidine-4-methylquinazoline (GMQ).

Besson, Thomas; Lingueglia, Eric; Salinas, Miguel

Besson, Thomas; Lingueglia, Eric; Salinas, Miguel.

Affiliation

Besson T; Université Côte d'Azur, CNRS, IPMC, France; LabEx Ion Channel Science and Therapeutics, IPMC, France.
Lingueglia E; Université Côte d'Azur, CNRS, IPMC, France; LabEx Ion Channel Science and Therapeutics, IPMC, France. Electronic address: lingueglia@ipmc.cnrs.fr.
Salinas M; Université Côte d'Azur, CNRS, IPMC, France; LabEx Ion Channel Science and Therapeutics, IPMC, France. Electronic address: salinas@ipmc.cnrs.fr.

Neuropharmacology ; 125: 429-440, 2017 Oct.

Article in En | MEDLINE | ID: mdl-28802647

Subject(s)

Acid Sensing Ion Channel Blockers/pharmacology; Acid Sensing Ion Channels/metabolism; Amiloride/pharmacology; Guanidines/pharmacology; Quinazolines/pharmacology; Animals; Elapid Venoms/pharmacology; Hydrogen-Ion Concentration; Membrane Potentials/drug effects; Membrane Potentials/physiology; Oocytes; Peptides/pharmacology; Protein Domains; Rats; Recombinant Fusion Proteins/metabolism; Spider Venoms/pharmacology; Xenopus

Key words

1-(4-methylquinazolin-2-yl)guanidine hydrochloride (PubChem CID: 12253739); Acid-Sensing Ion Channel (ASIC); Amiloride; Amiloride hydrochloride (PubChem CID: 16230); GMQ; Mambalgin; PcTx1; pH-dependent gating

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Acid Sensing Ion Channels / Acid Sensing Ion Channel Blockers / Amiloride / Guanidines Limits: Animals Language: En Journal: Neuropharmacology Year: 2017 Document type: Article Affiliation country: France Country of publication: United kingdom

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