Your browser doesn't support javascript.
loading
Auxin-Induced Modulation of ETTIN Activity Orchestrates Gene Expression in Arabidopsis.
Simonini, Sara; Bencivenga, Stefano; Trick, Martin; Østergaard, Lars.
Affiliation
  • Simonini S; Crop Genetics Department, John Innes Centre, NR4 7UH Norwich, United Kingdom.
  • Bencivenga S; Crop Genetics Department, John Innes Centre, NR4 7UH Norwich, United Kingdom.
  • Trick M; Computational and System Biology Department, John Innes Centre, NR4 7UH Norwich, United Kingdom.
  • Østergaard L; Crop Genetics Department, John Innes Centre, NR4 7UH Norwich, United Kingdom lars.ostergaard@jic.ac.uk.
Plant Cell ; 29(8): 1864-1882, 2017 Aug.
Article in En | MEDLINE | ID: mdl-28804059
The phytohormone auxin governs crucial developmental decisions throughout the plant life cycle. Auxin signaling is effectuated by auxin response factors (ARFs) whose activity is repressed by Aux/IAA proteins under low auxin levels, but relieved from repression when cellular auxin concentrations increase. ARF3/ETTIN (ETT) is a conserved noncanonical Arabidopsis thaliana ARF that adopts an alternative auxin-sensing mode of translating auxin levels into multiple transcriptional outcomes. However, a mechanistic model for how this auxin-dependent modulation of ETT activity regulates gene expression has not yet been elucidated. Here, we take a genome-wide approach to show how ETT controls developmental processes in the Arabidopsis shoot through its auxin-sensing property. Moreover, analysis of direct ETT targets suggests that ETT functions as a central node in coordinating auxin dynamics and plant development and reveals tight feedback regulation at both the transcriptional and protein-interaction levels. Finally, we present an example to demonstrate how auxin sensitivity of ETT-protein interactions can shape the composition of downstream transcriptomes to ensure specific developmental outcomes. These results show that direct effects of auxin on protein factors, such as ETT-TF complexes, comprise an important part of auxin biology and likely contribute to the vast number of biological processes affected by this simple molecule.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Arabidopsis / Gene Expression Regulation, Plant / Arabidopsis Proteins / DNA-Binding Proteins / Indoleacetic Acids Type of study: Prognostic_studies Language: En Journal: Plant Cell Journal subject: BOTANICA Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Arabidopsis / Gene Expression Regulation, Plant / Arabidopsis Proteins / DNA-Binding Proteins / Indoleacetic Acids Type of study: Prognostic_studies Language: En Journal: Plant Cell Journal subject: BOTANICA Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom