Amoxapine Demonstrates Incomplete Inhibition of ß-Glucuronidase Activity from Human Gut Microbiota.

Yang, Wei; Wei, Bin; Yan, Ru

Yang, Wei; Wei, Bin; Yan, Ru.

Affiliation

Yang W; 1 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China.
Wei B; 1 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China.
Yan R; 1 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China.

SLAS Discov ; 23(1): 76-83, 2018 01.

Article in En | MEDLINE | ID: mdl-28809607

Subject(s)

Amoxapine/pharmacology; Gastrointestinal Microbiome; Glucuronidase/antagonists & inhibitors; Glycoproteins/pharmacology; Amoxapine/chemistry; Bacteria/classification; Bacteria/enzymology; Bacteria/genetics; Bacterial Proteins/antagonists & inhibitors; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Dose-Response Relationship, Drug; Glucuronidase/genetics; Glucuronidase/metabolism; Glycoproteins/chemistry; Humans; Hydrolysis; Kinetics; Molecular Structure; Phylogeny

Key words

CPT-11induced toxicity; amoxapine; bacterial isolates; human gut microbiota; ß-glucuronidase inhibition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycoproteins / Gastrointestinal Microbiome / Glucuronidase / Amoxapine Type of study: Prognostic_studies Limits: Humans Language: En Journal: SLAS Discov Year: 2018 Document type: Article Affiliation country: China Country of publication: United States

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