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A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch.
Ramsden, Christopher E; Domenichiello, Anthony F; Yuan, Zhi-Xin; Sapio, Matthew R; Keyes, Gregory S; Mishra, Santosh K; Gross, Jacklyn R; Majchrzak-Hong, Sharon; Zamora, Daisy; Horowitz, Mark S; Davis, John M; Sorokin, Alexander V; Dey, Amit; LaPaglia, Danielle M; Wheeler, Joshua J; Vasko, Michael R; Mehta, Nehal N; Mannes, Andrew J; Iadarola, Michael J.
Affiliation
  • Ramsden CE; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA. chris.ramsden@nih.gov.
  • Domenichiello AF; Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20814, USA.
  • Yuan ZX; Department of Physical Medicine and Rehabilitation, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
  • Sapio MR; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.
  • Keyes GS; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  • Mishra SK; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.
  • Gross JR; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA.
  • Majchrzak-Hong S; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.
  • Zamora D; Department of Molecular Biomedical Sciences, NC State College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
  • Horowitz MS; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA.
  • Davis JM; Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20814, USA.
  • Sorokin AV; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.
  • Dey A; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
  • LaPaglia DM; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.
  • Wheeler JJ; Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.
  • Vasko MR; Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
  • Mehta NN; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20814, USA.
  • Mannes AJ; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20814, USA.
  • Iadarola MJ; Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA.
Sci Signal ; 10(493)2017 Aug 22.
Article in En | MEDLINE | ID: mdl-28831021
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Pruritus / Psoriasis / Systems Analysis / Linoleic Acid / Inflammation Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Pruritus / Psoriasis / Systems Analysis / Linoleic Acid / Inflammation Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States