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Human Genetic Determinants of Viral Diseases.
Kenney, Adam D; Dowdle, James A; Bozzacco, Leonia; McMichael, Temet M; St Gelais, Corine; Panfil, Amanda R; Sun, Yan; Schlesinger, Larry S; Anderson, Matthew Z; Green, Patrick L; López, Carolina B; Rosenberg, Brad R; Wu, Li; Yount, Jacob S.
Affiliation
  • Kenney AD; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210, USA; email: Adam.Kenney@osumc.edu , Temet.McMichael@osumc.edu , Anderson.3196@osu.edu , Jacob.Yount@osumc.edu.
  • Dowdle JA; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio 43210, USA; email: James.Dowdle@osumc.edu.
  • Bozzacco L; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • McMichael TM; Current affiliation: Target Information Group, Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA; email: leonia.bozzacco@gmail.com.
  • St Gelais C; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210, USA; email: Adam.Kenney@osumc.edu , Temet.McMichael@osumc.edu , Anderson.3196@osu.edu , Jacob.Yount@osumc.edu.
  • Panfil AR; Center of Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA; email: St-gelais.2@osu.edu , Panfil.6@osu.edu , Green.466@osu.edu , Wu.840@osu.edu.
  • Sun Y; Center of Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA; email: St-gelais.2@osu.edu , Panfil.6@osu.edu , Green.466@osu.edu , Wu.840@osu.edu.
  • Schlesinger LS; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email: Yansun@vet.upenn.edu , Lopezca@vet.upenn.edu.
  • Anderson MZ; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210, USA; email: Adam.Kenney@osumc.edu , Temet.McMichael@osumc.edu , Anderson.3196@osu.edu , Jacob.Yount@osumc.edu.
  • Green PL; Texas Biomedical Research Institute, San Antonio, Texas 78227, USA; email: lschlesinger@txbiomed.org.
  • López CB; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210, USA; email: Adam.Kenney@osumc.edu , Temet.McMichael@osumc.edu , Anderson.3196@osu.edu , Jacob.Yount@osumc.edu.
  • Rosenberg BR; Center of Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA; email: St-gelais.2@osu.edu , Panfil.6@osu.edu , Green.466@osu.edu , Wu.840@osu.edu.
  • Wu L; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email: Yansun@vet.upenn.edu , Lopezca@vet.upenn.edu.
  • Yount JS; Program in Immunogenomics, John C. Whitehead Presidential Fellows Program, The Rockefeller University, New York, NY 10065, USA.
Annu Rev Genet ; 51: 241-263, 2017 11 27.
Article in En | MEDLINE | ID: mdl-28853921
Much progress has been made in the identification of specific human gene variants that contribute to enhanced susceptibility or resistance to viral diseases. Herein we review multiple discoveries made with genome-wide or candidate gene approaches that have revealed significant insights into virus-host interactions. Genetic factors that have been identified include genes encoding virus receptors, receptor-modifying enzymes, and a wide variety of innate and adaptive immunity-related proteins. We discuss a range of pathogenic viruses, including influenza virus, respiratory syncytial virus, human immunodeficiency virus, human T cell leukemia virus, human papilloma virus, hepatitis B and C viruses, herpes simplex virus, norovirus, rotavirus, parvovirus, and Epstein-Barr virus. Understanding the genetic underpinnings that affect infectious disease outcomes should allow tailored treatment and prevention approaches in the future.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virus Diseases / Gene Expression Regulation / Genetic Predisposition to Disease / Host-Pathogen Interactions / Adaptive Immunity / Immunity, Innate Type of study: Prognostic_studies Limits: Humans Language: En Journal: Annu Rev Genet Year: 2017 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virus Diseases / Gene Expression Regulation / Genetic Predisposition to Disease / Host-Pathogen Interactions / Adaptive Immunity / Immunity, Innate Type of study: Prognostic_studies Limits: Humans Language: En Journal: Annu Rev Genet Year: 2017 Document type: Article Country of publication: United States