Feto-maternal osmotic balance at term. A prospective observational study.
J Perinat Med
; 46(2): 183-189, 2018 Feb 23.
Article
in En
| MEDLINE
| ID: mdl-28862988
ABSTRACT
OBJECTIVE:
We performed the present study to investigate the feto-maternal osmotic relationship at term with the hypothesis that, in contrast to the literature, maternal plasma osmolality is lower than fetal levels. In a previous study, we found that maternal plasma sodium at delivery was consistently lower than the sodium in the umbilical artery. Our aim was to corroborate these results with analysis of osmolality.METHODS:
Blood was sampled from 30 women immediately before cesarean section and from the umbilical artery and vein before cord clamping and osmolality, sodium and albumin were analyzed.RESULTS:
Maternal osmolality was (mean; 95% confidence interval) 287.0 (285.8-288.2) mOsmkg/kg, arterial cord osmolality was 289.4 (287.9-291.0) mOsm/kg and venous cord osmolality was 287.3 (286.0-288.5) mOsm/kg. The paired difference between maternal and umbilical arterial osmolality was mean (SD) -2.4 (3.3) mOsm/kg (P<0.001), between maternal and umbilical vein -0.3 (3.0) mOsm/kg (P=0.63) and between umbilical artery and vein -2.1 (2.8) mOsm/kg (P<0.001).CONCLUSION:
Maternal osmolality was significantly lower than arterial cord osmolality confirming our previous results. The feto-maternal osmotic gradient favors water transport from the mother to the fetus and may increase the fetal risk of water intoxication when the mother ingests or is administered large volumes of electrolyte free solutions.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osmolar Concentration
/
Umbilical Arteries
/
Umbilical Veins
/
Cesarean Section
/
Term Birth
/
Fetal Blood
/
Maternal-Fetal Exchange
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
J Perinat Med
Year:
2018
Document type:
Article
Affiliation country:
Sweden