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Three new kavalactone dimers from Piper methysticum (kava).
Yuan, Yao; Yang, Jian-Xiang; Nie, Ling-Hui; Li, Bai-Lin; Qin, Xu-Bing; Wu, Jie-Wei; Qiu, Sheng-Xiang.
Affiliation
  • Yuan Y; a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.
  • Yang JX; b College of Life Sciences , University of Chinese Academy of Sciences , Beijing 100049 , China.
  • Nie LH; a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.
  • Li BL; c College of Traditional Chinese Medicine , Southern Medical University , Guangzhou 510515 , China.
  • Qin XB; a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.
  • Wu JW; b College of Life Sciences , University of Chinese Academy of Sciences , Beijing 100049 , China.
  • Qiu SX; a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.
J Asian Nat Prod Res ; 20(9): 837-843, 2018 Sep.
Article in En | MEDLINE | ID: mdl-28868919
ABSTRACT
Three new dimeric kavalactones, designated as diyangonins A-C (1-3), along with two known analogs were isolated from the roots of Piper methysticum. Their structures were elucidated by means of extensive analysis of their 1D, 2D NMR, and mass spectroscopic data. All these dimers possess a skeleton featuring a cyclobutane ring connecting two kavalactone units in head-to-tail or head-to-head mode. Compounds 1-5 were evaluated for their cytotoxic activities against human tumor cell lines.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Kava / Lactones / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2018 Document type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Kava / Lactones / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2018 Document type: Article Affiliation country: China