Three new kavalactone dimers from Piper methysticum (kava).
J Asian Nat Prod Res
; 20(9): 837-843, 2018 Sep.
Article
in En
| MEDLINE
| ID: mdl-28868919
ABSTRACT
Three new dimeric kavalactones, designated as diyangonins A-C (1-3), along with two known analogs were isolated from the roots of Piper methysticum. Their structures were elucidated by means of extensive analysis of their 1D, 2D NMR, and mass spectroscopic data. All these dimers possess a skeleton featuring a cyclobutane ring connecting two kavalactone units in head-to-tail or head-to-head mode. Compounds 1-5 were evaluated for their cytotoxic activities against human tumor cell lines.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Kava
/
Lactones
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
J Asian Nat Prod Res
Journal subject:
BOTANICA
/
QUIMICA
Year:
2018
Document type:
Article
Affiliation country:
China