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Adenoid cystic carcinoma of the head and neck: a retrospective multicenter study.
Takebayashi, Shinji; Shinohara, Shogo; Tamaki, Hisanobu; Tateya, Ichiro; Kitamura, Morimasa; Mizuta, Masanobu; Tanaka, Shinzo; Kojima, Tsuyoshi; Asato, Ryo; Maetani, Toshiki; Ushiro, Koji; Kitani, Yoshiharu; Ichimaru, Kazuyuki; Honda, Keigo; Yamada, Koichiro; Omori, Koichi.
Affiliation
  • Takebayashi S; a Department of Otolaryngology - Head and Neck Surgery , Kobe City Medical Center General Hospital , Kobe , Japan.
  • Shinohara S; a Department of Otolaryngology - Head and Neck Surgery , Kobe City Medical Center General Hospital , Kobe , Japan.
  • Tamaki H; b Department of Otolaryngology - Head and Neck Surgery , Kurashiki Central Hospital , Kurashiki , Japan.
  • Tateya I; c Department of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine , Kyoto University , Kyoto , Japan.
  • Kitamura M; c Department of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine , Kyoto University , Kyoto , Japan.
  • Mizuta M; c Department of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine , Kyoto University , Kyoto , Japan.
  • Tanaka S; d Department of Otolaryngology - Head and Neck Surgery , Japanese Red Cross Osaka Hospital , Osaka , Japan.
  • Kojima T; e Department of Otolaryngology , Tenri Hospital , Tenri , Japan.
  • Asato R; f Department of Otolaryngology - Head and Neck Surgery , National Hospital Organization Kyoto Medical Center , Kyoto , Japan.
  • Maetani T; g Department of Otolaryngology - Head and Neck Surgery , Kitano Hospital Tazuke Medical Research Institute , Osaka , Japan.
  • Ushiro K; h Department of Otolaryngology , Japanese Red Cross Otsu Hospital , Otsu , Japan.
  • Kitani Y; i Department of Otorhinolaryngology - Head and Neck Surgery , Shizuoka General Hospital , Shizuoka , Japan.
  • Ichimaru K; j Department of Otolaryngology - Head and Neck Surgery , Kokura Memorial Hospital , Kokura , Japan.
  • Honda K; k Department of Otolaryngology , Japanese Red Cross Society Wakayama Medical Center , Wakayama , Japan.
  • Yamada K; k Department of Otolaryngology , Japanese Red Cross Society Wakayama Medical Center , Wakayama , Japan.
  • Omori K; c Department of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine , Kyoto University , Kyoto , Japan.
Acta Otolaryngol ; 138(1): 73-79, 2018 Jan.
Article in En | MEDLINE | ID: mdl-28899226
ABSTRACT

BACKGROUND:

Adenoid cystic carcinoma of the head and neck (ACCHN) is rare and difficult to study effective treatment at one institute. Our aim is to identify prognostic factors for this disease by conducting a multicenter study at 11 institutions in Japan.

METHODS:

A retrospective multicenter study of ACCHN was performed. One hundred and three patients were identified between 2006 and 2015. The overall survival (OS) rate for all patients was calculated, and OS, locoregional control (LRC) rate, or no distant metastasis (NDM) rate was calculated for patients in that the surgery was performed without distant metastasis (DM). Statistical analyses were performed.

RESULTS:

A significant difference with multivariate analysis was observed in patients in sublingual glands, stage IV and the use of radiation therapy ≥60Gy (sufficient RT) in OS for all patients. A significant difference was observed in the use of sufficient postoperative RT in the OS and the LRC rate, and in pathological surgical margins in the NDM rate.

CONCLUSION:

Sublingual glands or stage IV was a poorer, and sufficient RT was a better prognostic factor for ACCHN. Sufficient RT was effective to prevent local recurrence after surgical resection. Positive surgical margins caused an increase in DM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sublingual Gland Neoplasms / Carcinoma, Adenoid Cystic / Head and Neck Neoplasms Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Acta Otolaryngol Year: 2018 Document type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sublingual Gland Neoplasms / Carcinoma, Adenoid Cystic / Head and Neck Neoplasms Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Acta Otolaryngol Year: 2018 Document type: Article Affiliation country: Japan