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Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.
Charvin, Delphine; Pomel, Vincent; Ortiz, Millan; Frauli, Mélanie; Scheffler, Sophie; Steinberg, Edith; Baron, Luc; Deshons, Laurène; Rudigier, Rachel; Thiarc, Delphine; Morice, Christophe; Manteau, Baptiste; Mayer, Stanislas; Graham, Danielle; Giethlen, Bruno; Brugger, Nadia; Hédou, Gaël; Conquet, François; Schann, Stephan.
Affiliation
  • Charvin D; Prexton Therapeutics , 14 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
  • Pomel V; Prexton Therapeutics , 14 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
  • Ortiz M; Prexton Therapeutics , 14 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
  • Frauli M; Domain Therapeutics , 850 Boulevard Sébastien Brant, 67400 Illkirch-Strasbourg, France.
  • Scheffler S; Domain Therapeutics , 850 Boulevard Sébastien Brant, 67400 Illkirch-Strasbourg, France.
  • Steinberg E; Domain Therapeutics , 850 Boulevard Sébastien Brant, 67400 Illkirch-Strasbourg, France.
  • Baron L; Domain Therapeutics , 850 Boulevard Sébastien Brant, 67400 Illkirch-Strasbourg, France.
  • Deshons L; Domain Therapeutics , 850 Boulevard Sébastien Brant, 67400 Illkirch-Strasbourg, France.
  • Rudigier R; Prestwick Chemical , 220 Boulevard Gonthier d'Andernach, 67400 Illkirch-Strasbourg, France.
  • Thiarc D; Prestwick Chemical , 220 Boulevard Gonthier d'Andernach, 67400 Illkirch-Strasbourg, France.
  • Morice C; Prestwick Chemical , 220 Boulevard Gonthier d'Andernach, 67400 Illkirch-Strasbourg, France.
  • Manteau B; Domain Therapeutics , 850 Boulevard Sébastien Brant, 67400 Illkirch-Strasbourg, France.
  • Mayer S; Domain Therapeutics , 850 Boulevard Sébastien Brant, 67400 Illkirch-Strasbourg, France.
  • Graham D; EMD Serono , 45A Middlesex Turnpike, Billerica, Massachusetts 0182, United States.
  • Giethlen B; Prestwick Chemical , 220 Boulevard Gonthier d'Andernach, 67400 Illkirch-Strasbourg, France.
  • Brugger N; EMD Serono , 45A Middlesex Turnpike, Billerica, Massachusetts 0182, United States.
  • Hédou G; EMD Serono , 45A Middlesex Turnpike, Billerica, Massachusetts 0182, United States.
  • Conquet F; Prexton Therapeutics , 14 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
  • Schann S; Domain Therapeutics , 850 Boulevard Sébastien Brant, 67400 Illkirch-Strasbourg, France.
J Med Chem ; 60(20): 8515-8537, 2017 10 26.
Article in En | MEDLINE | ID: mdl-28902994
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Receptors, Metabotropic Glutamate / Drug Discovery / Antiparkinson Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: Switzerland Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Receptors, Metabotropic Glutamate / Drug Discovery / Antiparkinson Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: Switzerland Country of publication: United States