Urinary NT-proBNP levels and echocardiographic parameters for patent ductus arteriosus.
J Perinatol
; 37(12): 1319-1324, 2017 12.
Article
in En
| MEDLINE
| ID: mdl-28906496
ABSTRACT
OBJECTIVE:
Patent ductus arteriosus (PDA) is common in preterm infants and is associated with significant morbidities. B type natriuretic peptide (BNP) is synthesized in the ventricles secondary to volume overload and excreted as urinary N-terminal pro-brain natriuretic peptide (NT-proBNP). STUDYDESIGN:
We report an observational prospective study of 64 preterm infants with birth weight ⩽1000 g. Echocardiographic parameters were obtained from clinical echocardiograms performed in the first week of life. Urinary NT-proBNP/creatinine ratios (pg mg-1) were measured on the same day of the echocardiograms.RESULTS:
Infants with medium to large PDA (n=39) had significantly higher NT-proBNP/creatinine levels compared with infants with small PDA (n=10) (median (IQ range) 2333 (792-6166) vs 714 (271-1632) pg mg-1, P=0.01) and compared with infants with no PDA (n=15) (2333 (792-6166) vs 390 (134-1085) pg mg-1, P=0.0003). Urinary NT-proBNP/creatinine ratios were significantly lower post treatment if PDA closed (n=17), P=0.001 or if PDA became smaller after treatment (n=9), P=0.004. Urinary NT-proBNP/creatinine levels correlated with ductal diameter (P⩽0.0001), but not with LA/Ao ratio (P=0.69) or blood flow velocity through the ductus (P=0.06).CONCLUSION:
Our findings indicate that there is a positive correlation between ductal diameter and urinary NT-proBNP in preterm infants.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Echocardiography, Doppler, Color
/
Natriuretic Peptide, Brain
/
Ductus Arteriosus, Patent
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
/
Infant
Language:
En
Journal:
J Perinatol
Journal subject:
PERINATOLOGIA
Year:
2017
Document type:
Article
Affiliation country:
United States