Regulation of pannexin channels in the central nervous system by Src family kinases.
Neurosci Lett
; 695: 65-70, 2019 03 16.
Article
in En
| MEDLINE
| ID: mdl-28911820
ABSTRACT
Pannexins form single membrane channels that regulate the passage of ions, small molecules and metabolites between the intra- and extracellular compartments. In the central nervous system, these channels are integrated into numerous signaling cascades that shape brain physiology and pathology. Post-translational modification of pannexins is complex, with phosphorylation emerging as a prominent form of functional regulation. While much is still not known regarding the specific kinases and modified amino acids, recent reports support a role for Src family tyrosine kinases (SFK) in regulating pannexin channel activity. This review outlines the current evidence supporting SFK-dependent pannexin phosphorylation in the CNS and examines the importance of these modifications in the healthy and diseased brain.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Central Nervous System
/
Connexins
/
Src-Family Kinases
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurosci Lett
Year:
2019
Document type:
Article
Affiliation country:
Canada