Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14.

Frouco, Gonçalo; Freitas, Ferdinando B; Martins, Carlos; Ferreira, Fernando

Frouco, Gonçalo; Freitas, Ferdinando B; Martins, Carlos; Ferreira, Fernando.

Affiliation

Frouco G; CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. da Universidade Técnica, Lisboa, Portugal.
Freitas FB; CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. da Universidade Técnica, Lisboa, Portugal.
Martins C; CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. da Universidade Técnica, Lisboa, Portugal.
Ferreira F; CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. da Universidade Técnica, Lisboa, Portugal. Electronic address: fernandof@fmv.ulisboa.pt.

Virus Res ; 242: 24-29, 2017 10 15.

Article in En | MEDLINE | ID: mdl-28916365

Subject(s)

African Swine Fever Virus/drug effects; African Swine Fever Virus/physiology; Antiviral Agents/metabolism; Histones/metabolism; Phenylbutyrates/metabolism; Protein Processing, Post-Translational/drug effects; Virus Replication/drug effects; Acetylation/drug effects; Animals; Chlorocebus aethiops; Histone Deacetylase Inhibitors/metabolism; Vero Cells

Key words

African swine fever virus; Antivirals; Enrofloxacin; Histone deacetylases enzymes; Histone deacetylases inhibitors; Sodium phenylbutyrate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Phenylbutyrates / Virus Replication / Histones / Protein Processing, Post-Translational / African Swine Fever Virus Limits: Animals Language: En Journal: Virus Res Journal subject: VIROLOGIA Year: 2017 Document type: Article Affiliation country: Portugal

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