Randomized Controlled Trials in Hereditary Cancer Syndromes.
Surg Oncol Clin N Am
; 26(4): 729-750, 2017 10.
Article
in En
| MEDLINE
| ID: mdl-28923228
ABSTRACT
Conducting randomized controlled trials (RCTs) in patients with germline mutations in genes that predispose to adult-onset cancer is hampered by the rarity of these mutations, barriers to their identification, and challenges inherent to randomizing high-risk individuals as part of a clinical trial. Most of the clinically relevant RCTs have been conducted in 3 syndromes in only some of the high-risk genes for which clinical testing is currently available. This article reviews the surgical, screening, and chemoprevention RCTs in each of the syndromes in clinically relevant studies conducted in the past 10 years.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neoplastic Syndromes, Hereditary
/
Colorectal Neoplasms, Hereditary Nonpolyposis
/
Randomized Controlled Trials as Topic
/
Germ-Line Mutation
/
Chemoprevention
Type of study:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Language:
En
Journal:
Surg Oncol Clin N Am
Journal subject:
NEOPLASIAS
Year:
2017
Document type:
Article
Affiliation country:
United States