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Randomized Controlled Trials in Hereditary Cancer Syndromes.
Ramamurthy, Chethan; Chertock, Yana; Hall, Michael J.
Affiliation
  • Ramamurthy C; Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-9972, USA.
  • Chertock Y; Department of Clinical Genetics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-9972, USA.
  • Hall MJ; Department of Clinical Genetics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-9972, USA. Electronic address: Michael.Hall@fccc.edu.
Surg Oncol Clin N Am ; 26(4): 729-750, 2017 10.
Article in En | MEDLINE | ID: mdl-28923228
ABSTRACT
Conducting randomized controlled trials (RCTs) in patients with germline mutations in genes that predispose to adult-onset cancer is hampered by the rarity of these mutations, barriers to their identification, and challenges inherent to randomizing high-risk individuals as part of a clinical trial. Most of the clinically relevant RCTs have been conducted in 3 syndromes in only some of the high-risk genes for which clinical testing is currently available. This article reviews the surgical, screening, and chemoprevention RCTs in each of the syndromes in clinically relevant studies conducted in the past 10 years.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Syndromes, Hereditary / Colorectal Neoplasms, Hereditary Nonpolyposis / Randomized Controlled Trials as Topic / Germ-Line Mutation / Chemoprevention Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Language: En Journal: Surg Oncol Clin N Am Journal subject: NEOPLASIAS Year: 2017 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Syndromes, Hereditary / Colorectal Neoplasms, Hereditary Nonpolyposis / Randomized Controlled Trials as Topic / Germ-Line Mutation / Chemoprevention Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Language: En Journal: Surg Oncol Clin N Am Journal subject: NEOPLASIAS Year: 2017 Document type: Article Affiliation country: United States