A combination of alfaxalone, medetomidine and midazolam for the chemical immobilization of Rhesus macaque (Macaca mulatta): Preliminary results.
J Med Primatol
; 46(6): 332-336, 2017 12.
Article
in En
| MEDLINE
| ID: mdl-28940590
ABSTRACT
BACKGROUND:
Chemical immobilization of non-human primates can be required to perform scientific or veterinary procedure with different invasiveness degrees. This preliminary study was undertaken to assess the clinical effects of a combination of alfaxalone, medetomidine and midazolam (AMM).METHODS:
Seven rhesus macaques were chemically immobilized, for invasive veterinary procedures, with alfaxan 2 mg kg-1 , medetomidine 20 µg kg-1 and midazolam 0.3 mg kg-1 injected subcutaneously.RESULTS:
The alfaxalone combination induced surgical anaesthesia, with a complete absence of response to noxious stimuli, for at least 20 minutes. The total duration of anaesthesia was 56 ± 7 minutes, and the administration of atipamezole, to partially reverse the combination effects, did not appear to alter the depth of anaesthesia.CONCLUSION:
In conclusion, the AMM combination produced rapid onset general anaesthesia, following subcutaneous administration of a relatively low volume (0.28 mL/kg) of injectate.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnanediones
/
Midazolam
/
Anesthetics, Combined
/
Medetomidine
/
Immobilization
/
Macaca mulatta
Limits:
Animals
Language:
En
Journal:
J Med Primatol
Year:
2017
Document type:
Article
Affiliation country:
United kingdom