Asymmetric development of the nervous system.
Dev Dyn
; 247(1): 124-137, 2018 01.
Article
in En
| MEDLINE
| ID: mdl-28940676
ABSTRACT
The human nervous system consists of seemingly symmetric left and right halves. However, closer observation of the brain reveals anatomical and functional lateralization. Defects in brain asymmetry correlate with several neurological disorders, yet our understanding of the mechanisms used to establish lateralization in the human central nervous system is extremely limited. Here, we review left-right asymmetries within the nervous system of humans and several model organisms, including rodents, Zebrafish, chickens, Xenopus, Drosophila, and the nematode Caenorhabditis elegans. Comparing and contrasting mechanisms used to develop left-right asymmetry in the nervous system can provide insight into how the human brain is lateralized. Developmental Dynamics 247124-137, 2018. © 2017 Wiley Periodicals, Inc.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation, Developmental
/
Body Patterning
/
Nervous System
Limits:
Animals
/
Humans
Language:
En
Journal:
Dev Dyn
Journal subject:
ANATOMIA
Year:
2018
Document type:
Article