[Screen absorption enhancer for intranasal administration preparations of paeoniflorin based on nasal perfusion method in rats].
Zhongguo Zhong Yao Za Zhi
; 42(3): 493-497, 2017 Feb.
Article
in Zh
| MEDLINE
| ID: mdl-28952254
ABSTRACT
This experiment was aimed to screen the absorption enhancer for intranasal administration preparations of paeoniflorin. In this study, HPLC method for determination of paeoniflorin in perfusion liquid was established and the improved model of nasal perfusion in rats was used to screen out the species and amounts of absorption enhancer. In order to avoid the influence of the secretion and absorption of nasal cavity on the volume of perfusion fluid, the residual dose was calculated by using the volume correction method. Linear regression was carried out between the logarithm to the percentage of the residual dose and the corresponding time, and the slope of the regression line was exactly the absorption rate constant. Experimental results showed that hydroxypropyl-ß-cyclodextrin and water-soluble azone can significantly improve the nasal absorption of paeoniflorin. Furthermore, water-soluble azone had the highest absorption rate constant and the best promoting penetration effect on intranasal administration preparations of paeoniflorin. It was also found that when the mass concentration of water-soluble azone in the perfusion liquid increased from 5 gâ¢L⻹ to 20 gâ¢L⻹, the absorption rate constant was gradually increased and peaked at 20 gâ¢L⻹. When the mass concentration was increased to 30 gâ¢L⻹, the absorption rate constant was decreased, indicating that the best mass concentration of water-soluble azone was 20 gâ¢L⻹.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Administration, Intranasal
/
Monoterpenes
/
Glucosides
/
Nasal Mucosa
Limits:
Animals
Language:
Zh
Journal:
Zhongguo Zhong Yao Za Zhi
Journal subject:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Year:
2017
Document type:
Article
Affiliation country:
China