The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats.
Environ Toxicol Pharmacol
; 56: 204-209, 2017 Dec.
Article
in En
| MEDLINE
| ID: mdl-28961515
ABSTRACT
Fenitrothion is widely used organophosphate pesticide in agriculture and health programs, but besides, it causes several toxic effects. The present study was designed to evaluate the possible protective effects of selenium (0.5mg/kg b.w.) and vitamin C (100mg/kg b.w) on altered haematological, biochemical and oxidative stress parameters in the blood of rats orally treated with fenitrothion (20mg/kg b.w) for 30days. Fenitrothion caused changes in body weight, food and water intake, and some haematological and biochemical parameters. Fenitrothion altered the glutathione redox status (GSH and GSSG) and decreased activity of antioxidant enzymes (GSH-Px, GST, SOD and CAT), leading to a lipid peroxidation. Selenium and vitamin C, by improving the activity of antioxidants, reduced oxidative stress and a lipid peroxidation, maintaining the values of examined parameters to optimal levels. Therefore, selenium and vitamin C could be useful in providing protection of exposed non-target organisms including people from fenitrothion.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ascorbic Acid
/
Selenium
/
Lipid Peroxidation
/
Fenitrothion
/
Insecticides
Limits:
Animals
Language:
En
Journal:
Environ Toxicol Pharmacol
Year:
2017
Document type:
Article