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Multiparity activates interferon pathways in peritoneal adipose tissue and decreases susceptibility to ovarian cancer metastasis in a murine allograft model.
Loughran, Elizabeth A; Phan, Ryan C; Leonard, Annemarie K; Tarwater, Laura; Asem, Marwa; Liu, Yueying; Yang, Jing; Klymenko, Yuliya; Johnson, Jeff; Shi, Zonggao; Hilliard, Tyvette S; Blumenthaler, Marielle; Leevy, Matthew; Ravosa, Matthew J; Stack, M Sharon.
Affiliation
  • Loughran EA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Integrated Biomedical Sciences Graduate Program, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Phan RC; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Leonard AK; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Tarwater L; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Asem M; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Integrated Biomedical Sciences Graduate Program, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Liu Y; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Yang J; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Klymenko Y; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Johnson J; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Shi Z; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Hilliard TS; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Blumenthaler M; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Leevy M; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  • Ravosa MJ; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, USA; Department of Anthropology, University
  • Stack MS; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA. Electronic address: sstack@nd.edu.
Cancer Lett ; 411: 74-81, 2017 12 28.
Article in En | MEDLINE | ID: mdl-28964786
Ovarian cancer is the fifth leading cause of cancer deaths in U.S. women and the deadliest gynecologic malignancy. This lethality is largely due to the fact that most cases are diagnosed at metastatic stages of the disease when the prognosis is poor. Epidemiologic studies consistently demonstrate that parous women have a reduced risk of developing ovarian cancer, with a greater number of births affording greater protection; however little is known about the impact of parity on ovarian cancer metastasis. Here we report that multiparous mice are less susceptible to ovarian cancer metastasis in an age-matched syngeneic murine allograft model. Interferon pathways were found to be upregulated in healthy adipose tissue of multiparous mice, suggesting a possible mechanism for the multiparous-related protective effect against metastasis. This protective effect was found to be lost with age. Based on this work, future studies exploring therapeutic strategies which harness the multiparity-associated protective effect demonstrated here are warranted.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Parity / Peritoneum / Adipose Tissue / Interferons / Neoplasms, Glandular and Epithelial Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Pregnancy Language: En Journal: Cancer Lett Year: 2017 Document type: Article Affiliation country: United States Country of publication: Ireland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Parity / Peritoneum / Adipose Tissue / Interferons / Neoplasms, Glandular and Epithelial Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Pregnancy Language: En Journal: Cancer Lett Year: 2017 Document type: Article Affiliation country: United States Country of publication: Ireland