The influence of physicochemical properties on the reactivity and stability of acyl glucuronides <sup></sup>.

Camilleri, Patrick; Buch, Akshay; Soldo, Brandi; Hutt, Andrew J

The influence of physicochemical properties on the reactivity and stability of acyl glucuronides .

Camilleri, Patrick; Buch, Akshay; Soldo, Brandi; Hutt, Andrew J.

Affiliation

Camilleri P; a Bio-Chemical Solutions , Stevenage , UK.
Buch A; b Aerpio Therapeutics, Inc. , Cincinnati , OH , USA , and.
Soldo B; b Aerpio Therapeutics, Inc. , Cincinnati , OH , USA , and.
Hutt AJ; c Department of Pharmacy, Pharmacology and Postgraduate Medicine , University of Hertfordshire, College Lane , Hatfield , UK.

Xenobiotica ; 48(9): 958-972, 2018 Sep.

Article in En | MEDLINE | ID: mdl-28967291

Subject(s)

Glucuronides/chemistry; Glucuronides/pharmacokinetics; Animals; Carbon/chemistry; Drug Stability; Fatty Acids/chemistry; Half-Life; Humans; Structure-Activity Relationship; Tolmetin/analogs & derivatives; Tolmetin/chemistry; Tolmetin/pharmacokinetics

Key words

1-O-acyl-ß-d-glucuronides; acyl migration; carboxylic acids; electronic and steric properties; glucuronide conjugation; physicochemical properties

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glucuronides Limits: Animals / Humans Language: En Journal: Xenobiotica Year: 2018 Document type: Article Affiliation country: United kingdom

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