Aryl Hydrocarbon Receptor Ablation in Cardiomyocytes Protects Male Mice From Heart Dysfunction Induced by NKX2.5 Haploinsufficiency.

Wang, Qin; Fan, Yunxia; Kurita, Hisaka; Jiang, Min; Koch, Sheryl; Rao, Marepalli B; Rubinstein, Jack; Puga, Alvaro

Wang, Qin; Fan, Yunxia; Kurita, Hisaka; Jiang, Min; Koch, Sheryl; Rao, Marepalli B; Rubinstein, Jack; Puga, Alvaro.

Affiliation

Wang Q; Department of Environmental Health and Center for Environmental Genetics.
Fan Y; Department of Environmental Health and Center for Environmental Genetics.
Kurita H; Department of Environmental Health and Center for Environmental Genetics.
Jiang M; Department of Internal Medicine Cardiology Division, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267.
Koch S; Department of Internal Medicine Cardiology Division, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267.
Rao MB; Department of Environmental Health and Center for Environmental Genetics.
Rubinstein J; Department of Internal Medicine Cardiology Division, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267.
Puga A; Department of Environmental Health and Center for Environmental Genetics.

Toxicol Sci ; 160(1): 74-82, 2017 Nov 01.

Article in En | MEDLINE | ID: mdl-28973413

Subject(s)

Basic Helix-Loop-Helix Transcription Factors/deficiency; Cardiomegaly/prevention & control; Cardiomyopathy, Dilated/prevention & control; Haploinsufficiency; Homeobox Protein Nkx-2.5/deficiency; Myocytes, Cardiac/metabolism; Receptors, Aryl Hydrocarbon/deficiency; Ventricular Dysfunction/prevention & control; Ventricular Function; Age Factors; Animals; Basic Helix-Loop-Helix Transcription Factors/agonists; Basic Helix-Loop-Helix Transcription Factors/genetics; Cardiomegaly/genetics; Cardiomegaly/metabolism; Cardiomegaly/physiopathology; Cardiomyopathy, Dilated/genetics; Cardiomyopathy, Dilated/metabolism; Cardiomyopathy, Dilated/physiopathology; Disease Models, Animal; Environmental Pollutants/toxicity; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Homeobox Protein Nkx-2.5/genetics; Male; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac/drug effects; Phenotype; Polychlorinated Dibenzodioxins/toxicity; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon/agonists; Receptors, Aryl Hydrocarbon/genetics; Sex Factors; Stroke Volume; Ventricular Dysfunction/genetics; Ventricular Dysfunction/metabolism; Ventricular Dysfunction/physiopathology; Ventricular Function/drug effects

Key words

Nkx2.5; aryl hydrocarbon receptor; cardiac hypertrophy; cardiomyocytes; haploinsufficiency

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiomyopathy, Dilated / Ventricular Function / Cardiomegaly / Receptors, Aryl Hydrocarbon / Ventricular Dysfunction / Myocytes, Cardiac / Basic Helix-Loop-Helix Transcription Factors / Haploinsufficiency / Homeobox Protein Nkx-2.5 Type of study: Prognostic_studies Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2017 Document type: Article Country of publication: United States

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