L-Serine-Mediated Neuroprotection Includes the Upregulation of the ER Stress Chaperone Protein Disulfide Isomerase (PDI).

Dunlop, R A; Powell, J T; Metcalf, J S; Guillemin, G J; Cox, P A

Dunlop, R A; Powell, J T; Metcalf, J S; Guillemin, G J; Cox, P A.

Affiliation

Dunlop RA; Brain Chemistry Labs, Institute for Ethnomedicine, Jackson Hole, WY, USA.
Powell JT; Neuroinflammation Group, MND and Neurodegenerative Diseases Research Center, Macquarie University, Sydney, Australia.
Metcalf JS; Brain Chemistry Labs, Institute for Ethnomedicine, Jackson Hole, WY, USA.
Guillemin GJ; Brain Chemistry Labs, Institute for Ethnomedicine, Jackson Hole, WY, USA.
Cox PA; Neuroinflammation Group, MND and Neurodegenerative Diseases Research Center, Macquarie University, Sydney, Australia.

Neurotox Res ; 33(1): 113-122, 2018 Jan.

Article in En | MEDLINE | ID: mdl-28975502

Subject(s)

Endoplasmic Reticulum Stress/drug effects; Neuroprotection/drug effects; Protein Disulfide-Isomerases/metabolism; Serine/pharmacology; Up-Regulation/drug effects; Activating Transcription Factor 4/genetics; Activating Transcription Factor 4/metabolism; Amino Acids, Diamino/pharmacology; Apoptosis/drug effects; Caspase 3/genetics; Caspase 3/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Cyanobacteria Toxins; Humans; L-Lactate Dehydrogenase/metabolism; Nerve Degeneration/chemically induced; Nerve Degeneration/prevention & control; Neuroblastoma/pathology; Protein Disulfide-Isomerases/genetics; RNA, Messenger/metabolism; Signal Transduction/drug effects; X-Box Binding Protein 1/genetics; X-Box Binding Protein 1/metabolism

Key words

ER stress; L-BMAA; L-Serine; Neuroprotection; PDI; Unfolded protein response

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / Up-Regulation / Protein Disulfide-Isomerases / Endoplasmic Reticulum Stress / Neuroprotection Type of study: Prognostic_studies Limits: Humans Language: En Journal: Neurotox Res Journal subject: NEUROLOGIA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States

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