Angeloylated Germacranolides from Daucus virgatus and Their Plasmodium Transmission Blocking Activity.
J Nat Prod
; 80(10): 2787-2794, 2017 10 27.
Article
in En
| MEDLINE
| ID: mdl-28976194
ABSTRACT
Phytochemical investigation of the aerial parts of the Tunisian plant Daucus virgatus led to the isolation of eight new germacranolides named daucovirgolides A-H (1-8). The stereostructures of these sesquiterpene lactones, decorated by either one or two angeloyl groups, have been determined by a combination of MS, NMR spectroscopy, chemical derivatization, and comparison of experimental electronic circular dichroism curves with TDDFT-predicted data. Daucovirgolide G (7) proved to be the single member of this family to possess a marked inhibitory activity (92% at 50 µg/mL) on the development of Plasmodium early sporogonic stages, the nonpathogenic transmissible stages of malaria parasites, devoid of general cytotoxicity. The selective activity of daucovirgolide G points to the existence of strict structural requirements for this transmission-blocking activity and therefore of a well-defined, although yet unidentified, biological target.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apiaceae
/
Plant Components, Aerial
/
Sesquiterpenes, Germacrane
/
Antimalarials
Country/Region as subject:
Africa
Language:
En
Journal:
J Nat Prod
Year:
2017
Document type:
Article
Affiliation country:
Italy