Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering.
J Biomed Mater Res B Appl Biomater
; 106(5): 1637-1644, 2018 07.
Article
in En
| MEDLINE
| ID: mdl-28976640
ABSTRACT
Novel synthetic biomaterials able to support direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds-which are easily tuneable to form sheets/fibers-support growth, proliferation, and spatial organization of pancreatic cancer cells, indicating their great potential in cancer tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B Appl Biomater, 106B 1637-1644, 2018.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreatic Neoplasms
/
Biocompatible Materials
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Tissue Engineering
/
Nanotubes, Carbon
/
Tissue Scaffolds
Limits:
Humans
Language:
En
Journal:
J Biomed Mater Res B Appl Biomater
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2018
Document type:
Article
Affiliation country:
United kingdom
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA