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Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering.
Matta-Domjan, Brigitta; King, Alice; Totti, Stella; Matta, Csaba; Dover, George; Martinez, Patricia; Zakhidov, Anvar; La Ragione, Roberto; Macedo, Hugo; Jurewicz, Izabela; Dalton, Alan; Velliou, Eirini G.
Affiliation
  • Matta-Domjan B; Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, Faculty of Engineering & Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
  • King A; Department of Physics and Astronomy, School of Mathematical and Physical Sciences, University of Sussex, Brighton, BN1 9QH, UK.
  • Totti S; Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, Faculty of Engineering & Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
  • Matta C; Department of Veterinary Preclinical Sciences, School of Veterinary Science and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7AL, UK.
  • Dover G; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
  • Martinez P; Department of Physics, Faculty of Engineering & Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
  • Zakhidov A; NanoTech Institute, University of Texas at Dallas, Richardson, Texas, 75083-068875080.
  • La Ragione R; NanoTech Institute, University of Texas at Dallas, Richardson, Texas, 75083-068875080.
  • Macedo H; National University of Science and Technology, MISIS, Moscow, 119049, Russia.
  • Jurewicz I; Laboratory of Hybrid Nanophotonics and Optoelectronics, Department of Physics and Technology, ITMO University, St. Petersburg, 197101, Russia.
  • Dalton A; Department of Pathology and Infectious Diseases, School of Veterinary Science and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7AL, UK.
  • Velliou EG; Smart Separations Ltd., London, UK.
J Biomed Mater Res B Appl Biomater ; 106(5): 1637-1644, 2018 07.
Article in En | MEDLINE | ID: mdl-28976640
ABSTRACT
Novel synthetic biomaterials able to support direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds-which are easily tuneable to form sheets/fibers-support growth, proliferation, and spatial organization of pancreatic cancer cells, indicating their great potential in cancer tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B Appl Biomater, 106B 1637-1644, 2018.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Biocompatible Materials / Tissue Engineering / Nanotubes, Carbon / Tissue Scaffolds Limits: Humans Language: En Journal: J Biomed Mater Res B Appl Biomater Journal subject: ENGENHARIA BIOMEDICA Year: 2018 Document type: Article Affiliation country: United kingdom Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Biocompatible Materials / Tissue Engineering / Nanotubes, Carbon / Tissue Scaffolds Limits: Humans Language: En Journal: J Biomed Mater Res B Appl Biomater Journal subject: ENGENHARIA BIOMEDICA Year: 2018 Document type: Article Affiliation country: United kingdom Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA