Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets.
J Nutr Sci Vitaminol (Tokyo)
; 63(4): 237-243, 2017.
Article
in En
| MEDLINE
| ID: mdl-28978870
ABSTRACT
Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-ß1 in gel-filtered platelets, in addition to attenuating serum PF4 and ß-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Platelets
/
Secretory Vesicles
/
Diet, High-Fat
/
Glucosides
/
Anthocyanins
Limits:
Animals
Language:
En
Journal:
J Nutr Sci Vitaminol (Tokyo)
Year:
2017
Document type:
Article