Innate immune recognition of double-stranded RNA triggers increased expression of NKG2D ligands after virus infection.

Esteso, Gloria; Guerra, Susana; Valés-Gómez, Mar; Reyburn, Hugh T

Esteso, Gloria; Guerra, Susana; Valés-Gómez, Mar; Reyburn, Hugh T.

Affiliation

Esteso G; From the Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas (CNB-CSIC), 28049 Madrid and.
Guerra S; the Department of Preventive Medicine and Public Health, Universidad Autónoma, 28029 Madrid, Spain.
Valés-Gómez M; From the Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas (CNB-CSIC), 28049 Madrid and.
Reyburn HT; From the Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas (CNB-CSIC), 28049 Madrid and htreyburn@cnb.csic.es.

J Biol Chem ; 292(50): 20472-20480, 2017 12 15.

Article in En | MEDLINE | ID: mdl-28986447

Subject(s)

Gene Expression Regulation; Immunity, Innate; Killer Cells, Natural/metabolism; Lentivirus/physiology; NK Cell Lectin-Like Receptor Subfamily K/agonists; RNA, Viral/metabolism; Amino Acid Substitution; Animals; Cell Line; Cells, Cultured; Cricetinae; DEAD Box Protein 58/chemistry; DEAD Box Protein 58/genetics; DEAD Box Protein 58/metabolism; Gene Expression Regulation, Viral; Genes, Reporter; Humans; Interferon-Induced Helicase, IFIH1/chemistry; Interferon-Induced Helicase, IFIH1/genetics; Interferon-Induced Helicase, IFIH1/metabolism; Killer Cells, Natural/immunology; Killer Cells, Natural/virology; Lentivirus/immunology; Ligands; Mutation; NK Cell Lectin-Like Receptor Subfamily K/genetics; NK Cell Lectin-Like Receptor Subfamily K/metabolism; RNA/metabolism; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; Receptors, Immunologic; Recombinant Proteins/metabolism; Viral Proteins/genetics; Viral Proteins/metabolism

Key words

NKG2D; NKG2D ligands; cellular immune response; double-stranded RNA (dsRNA); dsRNA; natural killer cells (NK cells); pattern recognition receptor (PRR); self/non-self-discrimination; virus; virus infection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Viral / Killer Cells, Natural / Gene Expression Regulation / Lentivirus / NK Cell Lectin-Like Receptor Subfamily K / Immunity, Innate Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2017 Document type: Article

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