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Mouse Red Blood Cell-Mediated Rare Xenobiotic Phosphorylation of a Drug Molecule Not Intended to Be a Kinase Substrate.
Gu, Chungang; Wen, Shenghua; Doig, Peter; Gangl, Eric; Zheng, Xiaolan; Wang, Yanjun; Johannes, Jeffrey W.
Affiliation
  • Gu C; Oncology DMPK (C.G., E.G.), Oncology Biosciences (S.W., Y.W.), Discovery Sciences (P.D.), and Oncology Medicinal Chemistry (X.Z., J.W.J.), Innovative Medicines and Early Development, AstraZeneca, Waltham, Massachusetts chuck.gu@biogen.com.
  • Wen S; Oncology DMPK (C.G., E.G.), Oncology Biosciences (S.W., Y.W.), Discovery Sciences (P.D.), and Oncology Medicinal Chemistry (X.Z., J.W.J.), Innovative Medicines and Early Development, AstraZeneca, Waltham, Massachusetts.
  • Doig P; Oncology DMPK (C.G., E.G.), Oncology Biosciences (S.W., Y.W.), Discovery Sciences (P.D.), and Oncology Medicinal Chemistry (X.Z., J.W.J.), Innovative Medicines and Early Development, AstraZeneca, Waltham, Massachusetts.
  • Gangl E; Oncology DMPK (C.G., E.G.), Oncology Biosciences (S.W., Y.W.), Discovery Sciences (P.D.), and Oncology Medicinal Chemistry (X.Z., J.W.J.), Innovative Medicines and Early Development, AstraZeneca, Waltham, Massachusetts.
  • Zheng X; Oncology DMPK (C.G., E.G.), Oncology Biosciences (S.W., Y.W.), Discovery Sciences (P.D.), and Oncology Medicinal Chemistry (X.Z., J.W.J.), Innovative Medicines and Early Development, AstraZeneca, Waltham, Massachusetts.
  • Wang Y; Oncology DMPK (C.G., E.G.), Oncology Biosciences (S.W., Y.W.), Discovery Sciences (P.D.), and Oncology Medicinal Chemistry (X.Z., J.W.J.), Innovative Medicines and Early Development, AstraZeneca, Waltham, Massachusetts.
  • Johannes JW; Oncology DMPK (C.G., E.G.), Oncology Biosciences (S.W., Y.W.), Discovery Sciences (P.D.), and Oncology Medicinal Chemistry (X.Z., J.W.J.), Innovative Medicines and Early Development, AstraZeneca, Waltham, Massachusetts.
Drug Metab Dispos ; 45(12): 1345-1353, 2017 12.
Article in En | MEDLINE | ID: mdl-28986473
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphotransferases / Piperazines / Quinazolines / Xenobiotics / Tankyrases / Erythrocytes Limits: Animals / Female / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2017 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphotransferases / Piperazines / Quinazolines / Xenobiotics / Tankyrases / Erythrocytes Limits: Animals / Female / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2017 Document type: Article Country of publication: United States