Lung Diseases of the Elderly: Cellular Mechanisms.
Clin Geriatr Med
; 33(4): 473-490, 2017 11.
Article
in En
| MEDLINE
| ID: mdl-28991645
ABSTRACT
Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Cellular Senescence
/
Lung
/
Lung Diseases
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Aged
/
Humans
Language:
En
Journal:
Clin Geriatr Med
Journal subject:
GERIATRIA
Year:
2017
Document type:
Article
Affiliation country:
United States