[The complement system: a double edge sword in tumor progression]. / Le système du complément - Une épée à double tranchant dans la progression tumorale.
Med Sci (Paris)
; 33(10): 871-877, 2017 Oct.
Article
in Fr
| MEDLINE
| ID: mdl-28994383
ABSTRACT
The complement system is a key component of the innate immunity, playing a role in pathogen elimination and in host homeostasis. The complement system has been considered for long time as an anti-tumoral element. However, recent studies showed a pro-tumoral effect of complement and particularly of the anaphylatoxines C3a and C5a in a large variety of tumor types. Complement proteins act on different levels of tumor progression, affecting the tumor cells, the angiogenesis and the immune microenvironment. The impact of the complement system on tumor progression seems to be cancer type-dependent and this has to be taken into account in the establishment of potential biomarkers and development of therapeutic strategies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Complement System Proteins
/
Immunity, Innate
/
Neoplasms
Limits:
Animals
/
Humans
Language:
Fr
Journal:
Med Sci (Paris)
Journal subject:
MEDICINA
Year:
2017
Document type:
Article
Affiliation country:
France