Facile Coordination-Precipitation Route to Insoluble Metal Roussin's Black Salts for NIR-Responsive Release of NO for Anti-Metastasis.
ACS Appl Mater Interfaces
; 9(42): 36473-36477, 2017 Oct 25.
Article
in En
| MEDLINE
| ID: mdl-28994571
A facile and general coordination-precipitation method is developed to synthesize insoluble metal Roussin's black salts (Me-RBSs) as a new type of NIR-responsive NORMs. The weak-field ligand coordination of metal+-RBS- brings a NIR absorption effect of Me-RBSs, and further gives rise to the NIR adsorption-dependent NIR-responsive NO release profile. Intratumoral NIR-responsive release of NO effectively inhibits the growth and metastasis of the metastatic breast cancer. Aqueous insolubility of Me-RBSs ensures lower cytotoxicity and higher thermostability compared with traditional soluble RBSs. This work establishes a new class of NIR-sensitive NO donors, and may spark new inspiration for designing intelligent gas-releasing molecules.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Iron Compounds
/
Nitroso Compounds
Limits:
Humans
Language:
En
Journal:
ACS Appl Mater Interfaces
Journal subject:
BIOTECNOLOGIA
/
ENGENHARIA BIOMEDICA
Year:
2017
Document type:
Article
Country of publication:
United States