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Facile Coordination-Precipitation Route to Insoluble Metal Roussin's Black Salts for NIR-Responsive Release of NO for Anti-Metastasis.
Chen, Lijuan; He, Qianjun; Lei, Minyi; Xiong, Liwei; Shi, Kun; Tan, Liwei; Jin, Zhaokui; Wang, Tianfu; Qian, Zhiyong.
Affiliation
  • Chen L; State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu 610041, P. R. China.
  • He Q; National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University , Shenzhen 518060, Guangdong P. R. China.
  • Lei M; State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu 610041, P. R. China.
  • Xiong L; Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Wuhan Institute of Technology , Wuhan 430073, China.
  • Shi K; State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu 610041, P. R. China.
  • Tan L; State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu 610041, P. R. China.
  • Jin Z; National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University , Shenzhen 518060, Guangdong P. R. China.
  • Wang T; National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University , Shenzhen 518060, Guangdong P. R. China.
  • Qian Z; State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu 610041, P. R. China.
ACS Appl Mater Interfaces ; 9(42): 36473-36477, 2017 Oct 25.
Article in En | MEDLINE | ID: mdl-28994571
A facile and general coordination-precipitation method is developed to synthesize insoluble metal Roussin's black salts (Me-RBSs) as a new type of NIR-responsive NORMs. The weak-field ligand coordination of metal+-RBS- brings a NIR absorption effect of Me-RBSs, and further gives rise to the NIR adsorption-dependent NIR-responsive NO release profile. Intratumoral NIR-responsive release of NO effectively inhibits the growth and metastasis of the metastatic breast cancer. Aqueous insolubility of Me-RBSs ensures lower cytotoxicity and higher thermostability compared with traditional soluble RBSs. This work establishes a new class of NIR-sensitive NO donors, and may spark new inspiration for designing intelligent gas-releasing molecules.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Iron Compounds / Nitroso Compounds Limits: Humans Language: En Journal: ACS Appl Mater Interfaces Journal subject: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Year: 2017 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Iron Compounds / Nitroso Compounds Limits: Humans Language: En Journal: ACS Appl Mater Interfaces Journal subject: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Year: 2017 Document type: Article Country of publication: United States