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New Biguanides as Anti-Diabetic Agents, Part II: Synthesis and Anti-Diabetic Properties Evaluation of 1-Arylamidebiguanide Derivatives as Agents of Insulin Resistant Type II Diabetes.
Basyouni, Wahid M; Abbas, Samir Y; El Shehry, Mohamed F; El-Bayouki, Khairy A M; Aly, Hanan F; Arafa, Azza; Soliman, Mahmoud S.
Affiliation
  • Basyouni WM; National Research Centre, Department of Organometallic and Organometalloid Chemistry, Cairo, Egypt.
  • Abbas SY; National Research Centre, Department of Organometallic and Organometalloid Chemistry, Cairo, Egypt.
  • El Shehry MF; National Research Centre, Department of Pesticide Chemistry, Cairo, Egypt.
  • El-Bayouki KAM; National Research Centre, Department of Organometallic and Organometalloid Chemistry, Cairo, Egypt.
  • Aly HF; National Research Centre, Department of Therapeutic Chemistry, Cairo, Egypt.
  • Arafa A; National Research Centre, Department of Therapeutic Chemistry, Cairo, Egypt.
  • Soliman MS; National Research Centre, Department of Therapeutic Chemistry, Cairo, Egypt.
Arch Pharm (Weinheim) ; 350(11)2017 Nov.
Article in En | MEDLINE | ID: mdl-29027251
ABSTRACT
New 1-arylamidebiguanide hydrochloride salts were synthesized via reaction of hydrazide derivatives with dicyandiamide in acidic medium. The structure of the obtained derivatives was characterized by spectroscopic and elemental analysis tools. The anti-diabetic properties of the synthesized compounds were determined. Oral treatment of hyperglycemic rats with the synthesized biguanide derivatives showed a significant decrease of the elevated glucose in comparison with the anti-diabetic standard drug, metformin. The effects of the synthesized biguanide derivatives on the diabetic properties regarding liver function enzyme activities (AST, ALT, and ALP), lipid profiles (TC, TG, and TL), lipid peroxide, and nitrous oxide as well as histopathological characteristics were investigated and discussed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biguanides / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / Hypoglycemic Agents Limits: Animals Language: En Journal: Arch Pharm (Weinheim) Year: 2017 Document type: Article Affiliation country: Egypt
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biguanides / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / Hypoglycemic Agents Limits: Animals Language: En Journal: Arch Pharm (Weinheim) Year: 2017 Document type: Article Affiliation country: Egypt