Biocompatibility and Osseointegration of Titanium Implants with a Silver-Doped Polysiloxane Coating: An In Vivo Pig Model.
Int J Oral Maxillofac Implants
; 32(6): 13381345, 2017.
Article
in En
| MEDLINE
| ID: mdl-29028852
PURPOSE: To test the antimicrobial properties, surface topography, reaction of surrounding tissue (biocompatibility), and osseointegration of ultrathin implant surfaces containing polysiloxane and nanoscaled silver particles. MATERIALS AND METHODS: Implants with polysiloxane coating and nanoscaled silver particles (Ag/SiOxCy; HyProtect, Bio-Gate) were compared with implants with polysiloxane coating alone and with noncoated (grit-blasted and acid-etched) implants. A total of 72 implants were inserted into the calvaria of eight domestic pigs (nine implants each, three of each type). After 3 months, histologic sections were evaluated for inflammatory cell infiltration and bone implant contact. RESULTS: Roughness parameters did not differ between all three implant types. The Ag/SiOxCy coating exhibited a good antimicrobial effect in vitro and no sign of inflammatory cell infiltration in vivo. The noncoated implants demonstrated 10.85% and 14.48% more bone contact than the polysiloxane-coated implants (P = .003) and the Ag/SiOxCycoated implants (P ≤ .001), respectively. Osseointegration was not significantly different between the Ag/SiOxCycoated and polysiloxane-coated implants (P = .72). CONCLUSION: The osseointegration capability of the Ag/SiOxCy-coated implants was equal to that of the polysiloxane-coated implants but less than that of the grit-blasted and acid-etched implants. Because of the biocompatibility of the polysiloxane coating, further studies should be conducted in load-bearing models and in the oral cavity to investigate the antimicrobial effect of the embedded silver clusters.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Siloxanes
/
Silver
/
Titanium
/
Dental Implants
/
Osseointegration
/
Coated Materials, Biocompatible
/
Dental Implantation, Endosseous
Limits:
Animals
Language:
En
Journal:
Int J Oral Maxillofac Implants
Journal subject:
ODONTOLOGIA
Year:
2017
Document type:
Article
Country of publication:
United States