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Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.
Yamada, Ken; Brousseau, Margaret; Honma, Wataru; Iimura, Akiko; Imase, Hidetomo; Iwaki, Yuki; Kawanami, Toshio; LaSala, Daniel; Liang, Guiqing; Mitani, Hironobu; Nonomura, Kazuhiko; Ohmori, Osamu; Pan, Meihui; Rigel, Dean F; Umemura, Ichiro; Yasoshima, Kayo; Zhu, Guoming; Mogi, Muneto.
Affiliation
  • Yamada K; Novartis Institutes for BioMedical Research, Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139-4133, United States.
  • Brousseau M; Novartis Institutes for BioMedical Research , Novartis Pharma K.K., Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
  • Honma W; Novartis Institutes for BioMedical Research, Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139-4133, United States.
  • Iimura A; Novartis Institutes for BioMedical Research , Novartis Pharma K.K., Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
  • Imase H; Novartis Institutes for BioMedical Research , Novartis Pharma K.K., Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
  • Iwaki Y; Novartis Institutes for BioMedical Research, Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139-4133, United States.
  • Kawanami T; Novartis Institutes for BioMedical Research , Novartis Pharma K.K., Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
  • LaSala D; Novartis Institutes for BioMedical Research, Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139-4133, United States.
  • Liang G; Novartis Institutes for BioMedical Research , Novartis Pharma K.K., Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
  • Mitani H; Novartis Institutes for BioMedical Research, Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139-4133, United States.
  • Nonomura K; Novartis Institutes for BioMedical Research , Novartis Pharma K.K., Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
  • Ohmori O; Novartis Institutes for BioMedical Research , Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover, New Jersey 07936-1080, United States.
  • Pan M; Novartis Institutes for BioMedical Research, Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139-4133, United States.
  • Rigel DF; Novartis Institutes for BioMedical Research , Novartis Pharma K.K., Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
  • Umemura I; Novartis Institutes for BioMedical Research , Novartis Pharma K.K., Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
  • Yasoshima K; Novartis Institutes for BioMedical Research , Novartis Pharma K.K., Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.
  • Zhu G; Novartis Institutes for BioMedical Research, Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139-4133, United States.
  • Mogi M; Novartis Institutes for BioMedical Research , Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover, New Jersey 07936-1080, United States.
J Med Chem ; 60(20): 8466-8481, 2017 10 26.
Article in En | MEDLINE | ID: mdl-29035537
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Hypertriglyceridemia / Cholesterol Ester Transfer Proteins Limits: Aged / Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Hypertriglyceridemia / Cholesterol Ester Transfer Proteins Limits: Aged / Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: United States