Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells.

Zhang, Lisheng; Wu, Jiao-Hui; Otto, James C; Gurley, Susan B; Hauser, Elizabeth R; Shenoy, Sudha K; Nagi, Karim; Brian, Leigh; Wertman, Virginia; Mattocks, Natalie; Lawson, Jeffrey H; Freedman, Neil J

Zhang, Lisheng; Wu, Jiao-Hui; Otto, James C; Gurley, Susan B; Hauser, Elizabeth R; Shenoy, Sudha K; Nagi, Karim; Brian, Leigh; Wertman, Virginia; Mattocks, Natalie; Lawson, Jeffrey H; Freedman, Neil J.

Affiliation

Zhang L; Cardiology, Department of Medicine.
Wu JH; Cardiology, Department of Medicine.
Otto JC; Surgery.
Gurley SB; Nephrology, Department of Medicine.
Hauser ER; Biostatistics and Bioinformatics.
Shenoy SK; Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Nagi K; Cooperative Studies Program Epidemiology Center Durham Veterans Affairs Medical Center, Durham, NC, USA.
Brian L; Cardiology, Department of Medicine.
Wertman V; Cell Biology, Duke University Medical Center, Durham, NC, USA.
Mattocks N; Cardiology, Department of Medicine.
Lawson JH; Cell Biology, Duke University Medical Center, Durham, NC, USA.
Freedman NJ; Cardiology, Department of Medicine.

Cardiovasc Res ; 113(13): 1551-1559, 2017 Nov 01.

Article in En | MEDLINE | ID: mdl-29048463

Subject(s)

Arteriovenous Shunt, Surgical; Carotid Artery, Common/surgery; Interleukin-9/metabolism; Mast Cells/metabolism; Renal Insufficiency, Chronic/complications; Vascular Diseases/complications; Vena Cava, Inferior/transplantation; Animals; Apoptosis; Carotid Artery, Common/immunology; Carotid Artery, Common/metabolism; Carotid Artery, Common/pathology; Cells, Cultured; Disease Models, Animal; Endothelial Cells/metabolism; Endothelial Cells/pathology; Humans; Hyperplasia; Interleukin-9/immunology; Mast Cells/immunology; Mice, Inbred C57BL; Neointima; Phosphorylation; Renal Insufficiency, Chronic/immunology; Renal Insufficiency, Chronic/metabolism; Signal Transduction; Time Factors; Transcription Factor RelA/metabolism; Tumor Necrosis Factor-alpha/metabolism; Vascular Cell Adhesion Molecule-1/metabolism; Vascular Diseases/immunology; Vascular Diseases/metabolism; Vascular Diseases/pathology; Vena Cava, Inferior/immunology; Vena Cava, Inferior/metabolism; Vena Cava, Inferior/pathology

Key words

Cytokines; Endothelial cells; Mast cells; Neointimal hyperplasia; Smooth muscle cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vascular Diseases / Vena Cava, Inferior / Arteriovenous Shunt, Surgical / Interleukin-9 / Carotid Artery, Common / Renal Insufficiency, Chronic / Mast Cells Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Cardiovasc Res Year: 2017 Document type: Article Country of publication: United kingdom

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