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Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery.
Fan, Weiwei; Xia, Dengning; Zhu, Quanlei; Li, Xiuying; He, Shufang; Zhu, Chunliu; Guo, Shiyan; Hovgaard, Lars; Yang, Mingshi; Gan, Yong.
Affiliation
  • Fan W; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Xia D; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Zhu Q; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Li X; Department of Mechanical Engineering, University of Texas at Dallas, Richardson, TX 75080, United States.
  • He S; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhu C; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Guo S; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Hovgaard L; Oral Formulation Development, Novo Nordisk A/S, Maalov, 2760, Denmark.
  • Yang M; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
  • Gan Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: ygan@simm.ac.cn.
Biomaterials ; 151: 13-23, 2018 Jan.
Article in En | MEDLINE | ID: mdl-29055774
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Chitosan / Nanoparticles / Insulin / Intestinal Mucosa Aspects: Implementation_research Limits: Animals / Humans / Male Language: En Journal: Biomaterials Year: 2018 Document type: Article Affiliation country: China Country of publication: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Chitosan / Nanoparticles / Insulin / Intestinal Mucosa Aspects: Implementation_research Limits: Animals / Humans / Male Language: En Journal: Biomaterials Year: 2018 Document type: Article Affiliation country: China Country of publication: Netherlands