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Preparation and Characterization of Resorbable Bacterial Cellulose Membranes Treated by Electron Beam Irradiation for Guided Bone Regeneration.
An, Sung-Jun; Lee, So-Hyoun; Huh, Jung-Bo; Jeong, Sung In; Park, Jong-Seok; Gwon, Hui-Jeong; Kang, Eun-Sook; Jeong, Chang-Mo; Lim, Youn-Mook.
Affiliation
  • An SJ; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeollabuk-do 56212, Korea. asj@kaeri.re.kr.
  • Lee SH; Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea. romilove7@hanmail.net.
  • Huh JB; Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea. huhjb@pusan.ac.kr.
  • Jeong SI; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeollabuk-do 56212, Korea. sijeong@kaeri.re.kr.
  • Park JS; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeollabuk-do 56212, Korea. jspark75@kaeri.re.kr.
  • Gwon HJ; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeollabuk-do 56212, Korea. hjgwon@kaeri.re.kr.
  • Kang ES; Department of Prosthodontics, In-Je University Haeundae Paik Hospital, Busan 48108, Korea. prosth-kang@hanmail.net.
  • Jeong CM; Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea. cmjeong@pusan.ac.kr.
  • Lim YM; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeollabuk-do 56212, Korea. ymlim71@gmail.com.
Int J Mol Sci ; 18(11)2017 Oct 25.
Article in En | MEDLINE | ID: mdl-29068426
Bacterial cellulose (BC) is an excellent biomaterial with many medical applications. In this study, resorbable BC membranes were prepared for guided bone regeneration (GBR) using an irradiation technique for applications in the dental field. Electron beam irradiation (EI) increases biodegradation by severing the glucose bonds of BC. BC membranes irradiated at 100 kGy or 300 kGy were used to determine optimal electron beam doses. Electron beam irradiated BC membranes (EI-BCMs) were evaluated by scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, thermal gravimetric analysis (TGA), and using wet tensile strength measurements. In addition, in vitro cell studies were conducted in order to confirm the cytocompatibility of EI-BCMs. Cell viabilities of NIH3T3 cells on 100k and 300k EI-BCMs (100 kGy and 300 kGy irradiated BC membranes) were significantly greater than on NI-BCMs after 3 and 7 days (p < 0.05). Bone regeneration by EI-BCMs and their biodegradabilities were also evaluated using in vivo rat calvarial defect models for 4 and 8 weeks. Histometric results showed 100k EI-BCMs exhibited significantly larger new bone area (NBA; %) than 300k EI-BCMs at 8 weeks after implantation (p < 0.05). Mechanical, chemical, and biological analyses showed EI-BCMs effectively interacted with cells and promoted bone regeneration.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biocompatible Materials / Bone Regeneration / Cellulose / Guided Tissue Regeneration Limits: Animals Language: En Journal: Int J Mol Sci Year: 2017 Document type: Article Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biocompatible Materials / Bone Regeneration / Cellulose / Guided Tissue Regeneration Limits: Animals Language: En Journal: Int J Mol Sci Year: 2017 Document type: Article Country of publication: Switzerland