The association of HLA B*15:02 allele and Stevens-Johnson syndrome/toxic epidermal necrolysis induced by aromatic anticonvulsant drugs in a South Indian population.
Int J Dermatol
; 57(1): 70-73, 2018 Jan.
Article
in En
| MEDLINE
| ID: mdl-29076187
ABSTRACT
BACKGROUND:
The presence of HLA-B*1502 allele is considered a risk factor for development of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in patients taking aromatic anticonvulsant drugs like carbamazepine and phenytoin. The genetic association is ethnicity specific. Testing for HLA-B*1502 allele is suggested as a prerequisite before starting carbamazepine in certain ethnic groups. There are only a few/no studies from south India on HLA association of SJS/TEN.AIMS:
To identify any association between HLA-B*1502 allele and SJS/TEN induced by carbamazepine/phenytoin among native population. METHODS (INCLUDING SETTINGS, DESIGN, AND STATISTICAL ANALYSIS USED) A case-control study done in a tertiary care center at Kottayam in Kerala state of south India. Cases were 12 native patients who developed SJS/TEN owing to aromatic anticonvulsant drugs (phenytoin - 8; carbamazepine - 4), and controls were 11 persons tolerant to these drugs from unrelated families of the same ethnic group. HLA-B typing was done by PCR SSP method.RESULTS:
There was only one HLA-B*1502 carrier among cases and controls. He/she had SJS/TEN induced by carbamazepine.CONCLUSIONS:
Association of HLA-B*1502 with phenytoin-induced SJS/TEN is rare in the population studied. The one limitation of the study was the small sample size.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stevens-Johnson Syndrome
/
HLA-B15 Antigen
/
Anticonvulsants
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Int J Dermatol
Year:
2018
Document type:
Article
Affiliation country:
India