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Genetic and phenotypic characterization of the novel mouse substrain C57BL/6N Korl with increased body weight.
Choi, Kyung-Min; Jung, Jaehoon; Cho, Young Min; Kim, Kwondo; Kim, Mi-Gyeong; Kim, Jinho; Kim, Huibae; Shin, Hee Jung; Kim, Hae Deun; Chung, Seung-Tae; Cho, Seoae; Chung, Myeon-Woo.
Affiliation
  • Choi KM; Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of Korea.
  • Jung J; C&K Genomics, 26 Beobwon-ro 9-gil Bldg. C, #1008 (H business park) Songpa-gu, Seoul, 05836, Republic of Korea.
  • Cho YM; Department of Agricultural Biotechnology, Seoul National University, Kwan-ak St. 599, Kwan-ak Gu, Seoul, 151-742, Republic of Korea.
  • Kim K; Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of Korea.
  • Kim MG; C&K Genomics, 26 Beobwon-ro 9-gil Bldg. C, #1008 (H business park) Songpa-gu, Seoul, 05836, Republic of Korea.
  • Kim J; Interdisciplinary Program in Bioinformatics, Seoul National University, Kwan-ak St. 599, Kwan-ak Gu, Seoul, 151-741, Republic of Korea.
  • Kim H; Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of Korea.
  • Shin HJ; Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of Korea.
  • Kim HD; Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of Korea.
  • Chung ST; Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of Korea.
  • Cho S; Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of Korea.
  • Chung MW; Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of Korea.
Sci Rep ; 7(1): 14217, 2017 10 27.
Article in En | MEDLINE | ID: mdl-29079844
In inbred mouse lines, there is generally little genetic difference between individuals. This small genetic variability facilitates carrying out research on minute changes of various traits and the gene pool. Also, characterizing the diversity and detecting selective genetic and phenotypic signatures are crucial to understanding the genomic basis of a population and to identify specific patterns of evolutionary change. In this study, we investigated the underlying genetic profiles of a newly developed mouse strain, C57BL/6NKorl (Korl), established through sibling mating over 30 generations. To analyse the distinctive genomic features of Korl mice, we used whole-genome sequencing from six samples, which were compared to those of other C57BL/6N-based mouse strains. Korl strain-specific polymorphisms were identified and signatures of a selective sweep were detected. In particular, the candidate genes related to the increased body weight of the Korl strain were identified. Establishment of the genetic profile of Korl mice can provide insight into the inbreeding-induced changes to the gene pool, and help to establish this strain as a useful model for practical and targeted research purposes.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Body Weight Limits: Animals Language: En Journal: Sci Rep Year: 2017 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Body Weight Limits: Animals Language: En Journal: Sci Rep Year: 2017 Document type: Article Country of publication: United kingdom