Structural abnormality of substantia nigra induced by methamphetamine abuse.
Mov Disord
; 32(12): 1784-1788, 2017 Dec.
Article
in En
| MEDLINE
| ID: mdl-29082542
ABSTRACT
BACKGROUND:
Methamphetamine abuse has been linked to an increased risk of Parkinson's disease.OBJECTIVE:
The objective of this study was to investigate structural abnormality of the substantia nigra in past methamphetamine users using transcranial sonography.METHODS:
In a cross-sectional, observational study, echogenicity of the substantia nigra was assessed in 59 past methamphetamine users and 59 matched controls. The frequencies of an abnormal spatial extension of the substantia nigra as well as the average sizes of left and right substantia nigra were evaluated.RESULTS:
The average echogenic size of the substantia nigra was larger in methamphetamine users (0.22 ± 0.06 cm2 ) when compared with controls (0.17 ± 0.05 cm2 , P < .001). Furthermore, the frequency of enlarged, echogenic substantia nigra was increased in methamphetamine users (42% vs 12% in controls, P < .001). Partial correlation analysis revealed an association of echogenic substantia nigra size with estimated total lifetime intake of methamphetamine (r55 = 0.395, P = .002).CONCLUSIONS:
Current data link methamphetamine abuse in humans to injury of substantia nigra neurons and an increased risk of Parkinson's disease. © 2017 International Parkinson and Movement Disorder Society.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Substantia Nigra
/
Amphetamine-Related Disorders
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Central Nervous System Stimulants
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Methamphetamine
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Mov Disord
Journal subject:
NEUROLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Germany
Publication country:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA