Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH.

Tran, Melanie; Lee, Sang-Min; Shin, Dong-Ju; Wang, Li

Tran, Melanie; Lee, Sang-Min; Shin, Dong-Ju; Wang, Li.

Affiliation

Tran M; Department of Physiology and Neurobiology, and the Institute for Systems Genomics, University of Connecticut, Storrs, Connecticut, USA.
Lee SM; Department of Physiology and Neurobiology, and the Institute for Systems Genomics, University of Connecticut, Storrs, Connecticut, USA.
Shin DJ; Department of Physiology and Neurobiology, and the Institute for Systems Genomics, University of Connecticut, Storrs, Connecticut, USA.
Wang L; Department of Physiology and Neurobiology, and the Institute for Systems Genomics, University of Connecticut, Storrs, Connecticut, USA.

JCI Insight ; 2(21)2017 11 02.

Article in En | MEDLINE | ID: mdl-29093267

Subject(s)

Fatty Liver/metabolism; Inflammation/metabolism; MicroRNAs/metabolism; Non-alcoholic Fatty Liver Disease/metabolism; Signal Transduction; Animals; Arginase/metabolism; Biomarkers; Cell Line; Diet; Fatty Acids/metabolism; Fatty Liver/pathology; Female; Gene Expression; Humans; Interleukin-6/blood; Liver/injuries; Liver/metabolism; Liver/pathology; Macrophages/metabolism; Male; Metabolomics; Mice; Mice, Knockout; Neutrophils; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease/pathology; PPAR alpha; Sterol Regulatory Element Binding Protein 1; Toll-Like Receptor 4/metabolism; Transaminases/blood; Triglycerides

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / MicroRNAs / Fatty Liver / Non-alcoholic Fatty Liver Disease / Inflammation Limits: Animals / Female / Humans / Male Language: En Journal: JCI Insight Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States

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