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Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802.
Zheng, Yue-Ming; Wang, Wan-Fu; Li, Yan-Fen; Yu, Yong; Gao, Zhao-Bing.
Affiliation
  • Zheng YM; CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Wang WF; CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Li YF; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
  • Yu Y; CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Gao ZB; Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Acta Pharmacol Sin ; 39(4): 587-596, 2018 Apr.
Article in En | MEDLINE | ID: mdl-29094728
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenyl Ethers / Proline / NAV1.7 Voltage-Gated Sodium Channel / Voltage-Gated Sodium Channel Blockers / Analgesics Limits: Animals / Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: China Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenyl Ethers / Proline / NAV1.7 Voltage-Gated Sodium Channel / Voltage-Gated Sodium Channel Blockers / Analgesics Limits: Animals / Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: China Country of publication: United States