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Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.
Stiborová, Marie; Indra, Radek; Frei, Eva; Kopecková, Katerina; Schmeiser, Heinz H; Eckschlager, Tomás; Adam, Vojtech; Heger, Zbynek; Arlt, Volker M; Martínek, Václav.
Affiliation
  • Stiborová M; Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic.
  • Indra R; Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic.
  • Frei E; Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic.
  • Kopecková K; Department of Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84, 150 06 Prague 5, Czech Republic.
  • Schmeiser HH; Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
  • Eckschlager T; Department of Pediatric Hematology and Oncology, 2nd Medical Faculty, Charles University and University Hospital Motol, V Uvalu 84, 150 06 Prague 5, Czech Republic.
  • Adam V; Laboratory of Metallomics and Nanotechnology, Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300 Brno, Czech Republic.
  • Heger Z; Laboratory of Metallomics and Nanotechnology, Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300 Brno, Czech Republic.
  • Arlt VM; Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King's College London, London, SE1 9NH UK.
  • Martínek V; Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic.
Monatsh Chem ; 148(11): 1983-1991, 2017.
Article in En | MEDLINE | ID: mdl-29104319
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Monatsh Chem Year: 2017 Document type: Article Affiliation country: Czech Republic Country of publication: Austria
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Monatsh Chem Year: 2017 Document type: Article Affiliation country: Czech Republic Country of publication: Austria