The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesity.
Environ Res
; 160: 541-546, 2018 01.
Article
in En
| MEDLINE
| ID: mdl-29106953
ABSTRACT
BACKGROUND AND OBJECTIVES:
The pesticide metabolite p,p'-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p'-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p'-DDE with LV mass.METHODS:
p,p'-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques.RESULTS:
We found that p,p'-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p'-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%).CONCLUSION:
The obesogenic effect of p,p'-DDE is a major determinant responsible for the association of p,p'-DDE with LV mass.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hypertrophy, Left Ventricular
/
Dichlorodiphenyl Dichloroethylene
/
Environmental Pollutants
/
Heart Ventricles
/
Insecticides
/
Obesity
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Environ Res
Year:
2018
Document type:
Article