Acute reversible toxic encephalopathy during capecitabine and oxaliplatin treatment.
J Oncol Pharm Pract
; 25(2): 497-501, 2019 Mar.
Article
in En
| MEDLINE
| ID: mdl-29121830
ABSTRACT
INTRODUCTION:
Capecitabine is a fluoropyrimidine commonly used in the treatment of colorectal cancer which may cause central nervous system toxicity, namely cerebellar dysfunction. CASE REPORT We describe a 77-year-old man undergoing adjuvant treatment of colon cancer with capecitabine and oxaliplatin who presented with acute cerebellar ataxia and encephalopathy that progressed to coma. Diagnosis of toxic encephalopathy was made after the exclusion of alternative causes of neurological dysfunction and complete resolution of clinical findings with permanent discontinuation of chemotherapy.DISCUSSION:
When patients with cancer develop symptoms and signs of central nervous dysfunction, metabolic and infectious causes plus tumor involvement of central nervous system must be sought. However, chemotherapy may also cause toxicity to the central nervous system. Capecitabine is no exception, although cerebellar dysfunction is rarely reported.CONCLUSION:
Although rare, capecitabine-induced encephalopathy may be severe and physicians should be aware of this possible side effect.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antineoplastic Combined Chemotherapy Protocols
/
Colonic Neoplasms
/
Neurotoxicity Syndromes
/
Capecitabine
/
Oxaliplatin
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
J Oncol Pharm Pract
Journal subject:
FARMACIA
Year:
2019
Document type:
Article
Affiliation country:
Portugal