Pathological prolongation of action potential duration as a cause of the reduced alpha-adrenoceptor-mediated negative inotropy in streptozotocin-induced diabetic mice myocardium.
J Pharmacol Sci
; 135(3): 131-133, 2017 Nov.
Article
in En
| MEDLINE
| ID: mdl-29122532
ABSTRACT
Effect of pathological prolongation of action potential duration on the α-adrenoceptor-mediated negative inotropy was studied in streptozotocin-induced diabetic mice myocardium. In streptozotocin-treated mouse ventricular myocardium, which had longer duration of action potential than that in control mice, the negative inotropic response induced by phenylephrine was smaller than that in control mice. 4-Aminopyridine prolonged the action potential duration and decreased the negative inotropy in control mice. Cromakalim shortened the action potential duration and increased the negative inotropy in streptozotocin-treated mice. These results suggest that the reduced α-adrenoceptor-mediated inotropy in the diabetic mouse myocardium is partly due to its prolonged action potential.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Action Potentials
/
Receptors, Adrenergic, alpha
/
Diabetes Mellitus, Experimental
/
Myocardial Contraction
Limits:
Animals
Language:
En
Journal:
J Pharmacol Sci
Journal subject:
FARMACOLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Japan