Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age.
J Am Acad Dermatol
; 78(1): 29-39.e7, 2018 Jan.
Article
in En
| MEDLINE
| ID: mdl-29146147
ABSTRACT
BACKGROUND:
Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging.OBJECTIVE:
We evaluated molecular changes occurring in photoexposed and photoprotected skin of white women 20 to 74 years of age, some of whom appeared substantially younger than their chronologic age.METHODS:
Histologic and transcriptomics profiling were conducted on skin biopsy samples of photoexposed (face and dorsal forearm) or photoprotected (buttocks) body sites from 158 women. 23andMe genotyping determined genetic ancestry.RESULTS:
Gene expression and ontologic analysis revealed progressive changes from the 20s to the 70s in pathways related to oxidative stress, energy metabolism, senescence, and epidermal barrier; these changes were accelerated in the 60s and 70s. The gene expression patterns from the subset of women who were younger-appearing were similar to those in women who were actually younger.LIMITATIONS:
Broader application of these findings (eg, across races and Fitzpatrick skin types) will require further studies.CONCLUSIONS:
This study demonstrates a wide range of molecular processes in skin affected by aging, providing relevant targets for improving the condition of aging skin at different life stages and defining a molecular pattern of epidermal gene expression in women who appear younger than their chronologic age.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ultraviolet Rays
/
Skin Aging
/
Genetic Predisposition to Disease
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
J Am Acad Dermatol
Year:
2018
Document type:
Article